The Role of the Muscle Secretome in Health and Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Role of the Muscle Secretome in Health and Disease write by Céline Aguer. This book was released on 2020-11-19. The Role of the Muscle Secretome in Health and Disease available in PDF, EPUB and Kindle. This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
The Cellular Secretome and Organ Crosstalk
The Cellular Secretome and Organ Crosstalk - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Cellular Secretome and Organ Crosstalk write by Juergen Eckel. This book was released on 2018-06-12. The Cellular Secretome and Organ Crosstalk available in PDF, EPUB and Kindle. The Cellular Secretome and Organ Crosstalk focuses on the release of peptides and proteins from different organs and their specific functions in metabolic regulation and cell- and organ crosstalk. The book is written for experts in the field, however, for each topic, helpful references are included. The book also includes technical sections that summarize the state-of-the-art of secretome and crosstalk analysis. This book fulfills the need for a resource that comprehensively describes the current knowledge of secretome biology in health and disease. Communication between different organs involves lipids and other small molecules and a host of proteins and peptides comprising the secretome of different organs (organokinome). More than 600 adipokines have been identified, and an increasing number of hepatokines and myokines have recently been discovered with mostly unknown physiological impact. Importantly, an aberrant signature of the organokinome may be critically underlying a variety of metabolic diseases and may determine the individual susceptibility to disease development. Summarizes our current knowledge on the secretome of different cells and tissues Dissects auto-, para- and endocrine functions of major secreted peptides and proteins Analyzes the secretory malfunction of different cells and its impact for disease development Authored by a leader in the field, presenting a coherent view on this very complex topic
A New Component of Skeletal Muscle Secretome Impact on Beta Cells and Prevent TNF-a and Cytomix Effect on Beta-cells
A New Component of Skeletal Muscle Secretome Impact on Beta Cells and Prevent TNF-a and Cytomix Effect on Beta-cells - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook A New Component of Skeletal Muscle Secretome Impact on Beta Cells and Prevent TNF-a and Cytomix Effect on Beta-cells write by Bouzakri Karim. This book was released on 2017. A New Component of Skeletal Muscle Secretome Impact on Beta Cells and Prevent TNF-a and Cytomix Effect on Beta-cells available in PDF, EPUB and Kindle. A new positive component of skeletal muscle secretome impact on beta cells and prevent TNF-alpha and cytomix effect on beta cells.Karim Bouzakri, Julien Cherfan, Harzo Hamdard, Carole Mura, Claude Peronet, and Michel Pinget.UMR DIATHEC, EA 7294, Centre Europu00e9en du2019Etude du Diabu00e8te, Universitu00e9 de Strasbourg (UdS), Boulevard Renu00e9 Leriche 67200 Strasbourg, FranceBackground and aims: Inter-organ crosstalk including possible communication between skeletal muscle and beta cells is an important component of normal physiology that may contribute towards the pathophysiology of type 2 diabetes. Indeed, skeletal muscle cells secrete different sets of soluble proteins (myokines) which could act positively or negatively (in health and disease respectively) on the function of distant tissues including pancreatic islets. We have observed that conditioned medium from skeletal muscle of healthy individuals has positive effects on beta cell function. A new myokine, was identified as a cytokine regulated by muscle fiber type. The major aim of this study was to explore the impact of our new myokine (Myo X) on primary sorted beta cells under control conditions and after exposure to TNF-u03b1 or insulin resistance condition medium from skeletal muscle cells.Materials and methods: All studies were performed using sorted rat primary beta cells and human islets exposed to Myo X for 24h. Glucose-stimulated insulin secretion (GSIS) and glucagon secretion was measured by radioimmunoassay and ELISA after 1h at 2.8 mmol/l and/or 1h at 16.7mmol/l glucose. Cell death and proliferation were measured by TUNEL assay and BrdU incorporation respectively. To study the potential beneficial/protective effects of our myokine, beta cells were exposed to it for 24h alone or with addition 20 ng/ml TNF-u03b1 alone or insulin resistance condition medium from skeletal muscle cells. Data are mean u00b1 SE for 5-8 independent experiments.Results: Myo X treatment of rat primary beta cells and human islets for 24h increased GSIS (control: 12.4 u00b1 3.2% content/h; 1u00b5g/ml Myo X: 15.08 u00b1 3.8%*; 10 u00b5g/ml Myo X: 14.1 u00b1 1.8%*; *p
Muscle Regeneration
Muscle Regeneration - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Muscle Regeneration write by Alexander Mauro. This book was released on 1979. Muscle Regeneration available in PDF, EPUB and Kindle.
Skeletal Muscle Fatigue in Health and Disease
Skeletal Muscle Fatigue in Health and Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Skeletal Muscle Fatigue in Health and Disease write by Matthew J. Rossman. This book was released on 2012. Skeletal Muscle Fatigue in Health and Disease available in PDF, EPUB and Kindle.
