The Use of Bedaquiline in the Treatment of Multidrug-resistant Tuberculosis - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Use of Bedaquiline in the Treatment of Multidrug-resistant Tuberculosis write by World Health Organization. This book was released on 2015-04-20. The Use of Bedaquiline in the Treatment of Multidrug-resistant Tuberculosis available in PDF, EPUB and Kindle. WHO estimates that up to half a million new cases of multidrug-resistant tuberculosis (MDR-TB) occur worldwide, each year. Current treatment regimens for MDR-TB present many challenges: treatment lasts 20 months or more, requiring daily administration of drugs that are more toxic, less effective, and far more expensive than those used to treat drug-susceptible TB. Globally, less than half of all patients who start MDR-TB therapy are treated successfully. For the first time in over 40 years, a new TB drug with a novel mechanism of action - bedaquiline- is available, and was granted accelerated approval by the United States Food and Drug Administration in December 2012. There is considerable interest in the potential of this drug to treat MDR-TB. However, information about this new drug remains limited. It has only been through two Phase IIb trials for safety and efficacy. The World Health Organization (WHO) is therefore issuing "interim policy guidance". This interim guidance provides advice on the inclusion of bedaquiline in the combination therapy of MDR-TB in accordance with the existing WHO Guidelines for the Programmatic Management of Drug-resistant TB (2011 Update).
WHO consolidated guidelines on tuberculosis. Module 4
WHO consolidated guidelines on tuberculosis. Module 4 - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook WHO consolidated guidelines on tuberculosis. Module 4 write by World Health Organization. This book was released on 2022-04-30. WHO consolidated guidelines on tuberculosis. Module 4 available in PDF, EPUB and Kindle. Between 2011 and 2019, WHO has developed and issued evidence-based policy recommendations on the treatment and care of patients with DR-TB. These policy recommendations have been presented in several WHO documents and their associated annexes, including the WHO Consolidated Guidelines on Drug Resistant Tuberculosis Treatment, issued by WHO in March 2019. The policy recommendations in each of these guidelines have been developed by WHO-convened Guideline Development Groups, using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach to summarize the evidence, and formulate policy recommendations and accompanying remarks. The present WHO Consolidated Guidelines on Tuberculosis, Module 4: Treatment - Drug-Resistant Tuberculosis Treatment includes a comprehensive set of WHO recommendations for the treatment and care of DR-TB. The document includes two new recommendations, one on the composition of shorter regimens and one on the use of the BPaL regimen (i.e. bedaquiline, pretomanid and linezolid). In addition, the consolidated guidelines include existing recommendations on treatment regimens for isoniazid-resistant TB and MDR/RR-TB, including longer regimens, culture monitoring of patients on treatment, the timing of antiretroviral therapy (ART) in MDR/RR-TB patients infected with the human immunodeficiency virus (HIV), the use of surgery for patients receiving MDR-TB treatment, and optimal models of patient support and care. The guidelines are to be used primarily in national TB programmes, or their equivalents in Ministries of Health, and for other policy-makers and technical organizations working on TB and infectious diseases in public and private sectors and in the community.
WHO consolidated guidelines on drug-resistant tuberculosis treatment
WHO consolidated guidelines on drug-resistant tuberculosis treatment - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook WHO consolidated guidelines on drug-resistant tuberculosis treatment write by World Health Organization. This book was released on 2018-11-07. WHO consolidated guidelines on drug-resistant tuberculosis treatment available in PDF, EPUB and Kindle. Tuberculosis (TB) strains with drug resistance (DR-TB) are more difficult to treat than drug-susceptible ones, and threaten global progress towards the targets set by the End TB Strategy of the World Health Organization (WHO). There is thus a critical need for evidence-based policy recommendations on the treatment and care of patients with DR-TB, based on the most recent and comprehensive evidence available. In this regard, the WHO consolidated guidelines on drug-resistant tuberculosis treatment fulfil the mandate of WHO to inform health professionals in Member States on how to improve treatment and care for patients with DR-TB. Between 2011 and 2018, WHO has developed and issued evidence-based policy recommendations on the treatment and care of patients with DR-TB. These policy recommendations have been presented in several WHO documents and their associated annexes, including the WHO treatment guidelines for multidrug- and rifampicin-resistant tuberculosis, 2018 update, issued by WHO in December 2018. The policy recommendations in each of these guidelines have been developed by WHO-convened Guideline Development Groups (GDGs), using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach to summarize the evidence, and formulate policy recommendations and accompanying remarks. The present Consolidated guidelines include a comprehensive set of WHO recommendations for the treatment and care of DR-TB, derived from these WHO guidelines documents. The consolidated guidelines include policy recommendations on treatment regimens for isoniazid-resistant TB (Hr-TB) and MDR/RR-TB, including longer and shorter regimens, culture monitoring of patients on treatment, the timing of antiretroviral therapy (ART) in MDR/RR-TB patients infected with the human immunodeficiency virus (HIV), use of surgery for patients receiving MDR-TB treatment, and optimal models of patient support and care.
Global Tuberculosis Report 2014
Global Tuberculosis Report 2014 - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Global Tuberculosis Report 2014 write by World Health Organization. This book was released on 2014. Global Tuberculosis Report 2014 available in PDF, EPUB and Kindle. Some volumes for 2014 includes CD-ROM for 2014 key indicators.
Guidelines for the Programmatic Management of Drug-resistant Tuberculosis
Guidelines for the Programmatic Management of Drug-resistant Tuberculosis - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Guidelines for the Programmatic Management of Drug-resistant Tuberculosis write by World Health Organization. This book was released on 2008. Guidelines for the Programmatic Management of Drug-resistant Tuberculosis available in PDF, EPUB and Kindle. The emergence of extensively drug-resistant strains of tuberculosis, especially in countries with a high prevalence of human immunodeficiency virus, is a serious threat to global public health and jeopardizes efforts to effectively control the disease. This publication offers updated recommendations for the diagnosis and management of drug-resistant tuberculosis in a variety of geographical, economic and social settings, and the recording of data that enables the monitoring and evaluation of programs.--Publisher's description.
