Pre-mRNA Processing - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Pre-mRNA Processing write by Angus I. Lamond. This book was released on 2014-08-23. Pre-mRNA Processing available in PDF, EPUB and Kindle. he past fifteen years have seen tremendous growth in our understanding of T the many post-transcriptional processing steps involved in producing func tional eukaryotic mRNA from primary gene transcripts (pre-mRNA). New processing reactions, such as splicing and RNA editing, have been discovered and detailed biochemical and genetic studies continue to yield important new insights into the reaction mechanisms and molecular interactions involved. It is now apparent that regulation of RNA processing plays a significant role in the control of gene expression and development. An increased understanding of RNA processing mechanisms has also proved to be of considerable clinical importance in the pathology of inherited disease and viral infection. This volume seeks to review the rapid progress being made in the study of how mRNA precursors are processed into mRNA and to convey the broad scope of the RNA field and its relevance to other areas of cell biology and medicine. Since one of the major themes of RNA processing is the recognition of specific RNA sequences and structures by protein factors, we begin with reviews of RNA-protein interactions. In chapter 1 David Lilley presents an overview of RNA structure and illustrates how the structural features of RNA molecules are exploited for specific recognition by protein, while in chapter 2 Maurice Swanson discusses the structure and function of the large family of hnRNP proteins that bind to pre-mRNA. The next four chapters focus on pre-mRNA splicing.
Transcription and Splicing
Transcription and Splicing - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Transcription and Splicing write by B. D. Hames. This book was released on 1988. Transcription and Splicing available in PDF, EPUB and Kindle. This book gives a co-ordinated review of our present knowledge of eukaryotic RNA synthesis.
Spliceosomal Pre-mRNA Splicing
Spliceosomal Pre-mRNA Splicing - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Spliceosomal Pre-mRNA Splicing write by Klemens J. Hertel. This book was released on 2014-02-21. Spliceosomal Pre-mRNA Splicing available in PDF, EPUB and Kindle. Providing a guide to classical experimental approaches to decipher splicing mechanisms and experimental strategies that rely on novel multi-disciplinary approaches, Spliceosomal Pre-mRNA Splicing: Methods and Protocols describes the theory of alternative pre-mRNA splicing in seven introductory chapters and then introduces protocols and their theoretical background relevant for a variety of experimental research. These protocol chapters cover basic methods to detect splicing events, analyses of alternative pre-mRNA splicing in vitro and in vivo manipulation of splicing events and high-throughput and bioinformatic analyses of alternative splicing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Spliceosomal Pre-mRNA Splicing: Methods and Protocols will aid newcomers and seasoned molecular biologists in understanding the fascinating world of alternative splicing with the ultimate goal of paving the way for many new discoveries to come.
Eukaryotic MRNA Processing
Eukaryotic MRNA Processing - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Eukaryotic MRNA Processing write by Adrian Krainer. This book was released on 1997. Eukaryotic MRNA Processing available in PDF, EPUB and Kindle. This volume focuses on the major aspects of post-transcriptional mRNA processing in the nucleus of eukaryotic cells. Each of the described mRNA reactions is required for proper gene expression and can also serve as a control point for regulating the expression of many genes, for example duringembryonic development or in different cell types. The different chapters review the assembly of newly synthesized nuclear mRNA transcripts into hnRNP particles and catalytically active spliceosomes; the structure and mechanism of action of small nuclear ribonucleoprotein particles and proteinfactors that catalyse pre-mRNA splicing in mammalian cells and in yeast; the regulation of gene expression and generation of protein isoform diversity by alternative splicing; the mechanisms of 3' end cleavage and polyadenylation; the architecture of the cell nucleus in relation to these processesand to the localization of the relevant substrates and factors; the diverse mechanisms of RNA processing by ribozymes and their potential relevance for nuclear mRNA processing; the mechanism of spliced-leader addition by trans-splicing in nematodes and trypanosomes; and the process ofinsertion/deletion mRNA editing in kinetoplasmid protozoa. In each chapter, leading researchers have provided detailed, critical reviews of the history, experimental approaches, major advances, current ideas and models, as well as future directions, for each of these active areas of research.
Cell Biology by the Numbers
Cell Biology by the Numbers - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Cell Biology by the Numbers write by Ron Milo. This book was released on 2015-12-07. Cell Biology by the Numbers available in PDF, EPUB and Kindle. A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid
