Ubiquitin and the Biology of the Cell - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Ubiquitin and the Biology of the Cell write by Jan-Michael Peters. This book was released on 1998-05-31. Ubiquitin and the Biology of the Cell available in PDF, EPUB and Kindle. The last several years have been a landmark period in the ubiquitin field. The breadth of ubiquitin's roles in cell biology was first sketched, and the importance of ubiquitin-dependent proteolysis as a regulatory mechanism gained general acceptance. The many strands of work that led to this new perception are re counted in this book. A consequence of this progress is that the field has grown dramatically since the first book on ubiquitin was published almost a decade ago [M. Rechsteiner (ed. ), Ubiquitin, Plenum Press, 1988]. In this span, students of the cell cycle, transcription, signal transduction, protein sorting, neuropathology, cancer, virology, and immunology have attempted to chart the role of ubi quit in in their particular experimental systems, and this integration of the field into cell biology as a whole continues at a remarkable pace. We hope that for active researchers in the field as well as for newcomers and those on the fence, this book will prove helpful for its breadth, historical perspective, and practical tips. Structural data are now available on many of the components of the ubiquitin pathway. The structures have provided basic insights into the unusual biochemical mechanisms of ubiquitination and proteasome-mediated proteolysis. Because high-speed computer graphics can convey structures more effectively than print media, we have supplemented the figures of the book with a Worldwide Web site that can display the structures in a flexible, viewer-controlled format.
The Ubiquitin System
The Ubiquitin System - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Ubiquitin System write by Milton J. Schlesinger. This book was released on 1988. The Ubiquitin System available in PDF, EPUB and Kindle.
Ubiquitin Proteasome System
Ubiquitin Proteasome System - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Ubiquitin Proteasome System write by Aldrin V. Gomes. This book was released on 2018. Ubiquitin Proteasome System available in PDF, EPUB and Kindle. Over the last decade, major advancements in our understanding of the ubiquitin-proteasome system (UPS) have occurred. This book focuses on recent trends in the UPS. The UPS is possibly the most complex of all intracellular pathways as close to 7% of all genes in the human genome make up part of the UPS. This complex system serves as an essential role in intracellular protein degradation, and because of its critical function, improper functioning of the UPS is associated with nearly all know diseases, including cancer, cardiovascular disease, and neurological diseases. The proteolytic component of the UPS is the proteasome, a multicatalytic complex found in the nucleus and cytoplasm. Another form of the proteasome, the immunoproteasome, is less abundant than the constitutive proteasome, but is important in immune response and degradation of oxidized proteins, and recent research suggests that it may be important in longevity. The articles in this book discuss recent findings which indicate that mutations in proteins involved with the UPS are associated with genetic diseases such as familial dilated cardiomyopathy, Nakajo syndrome, and spinal muscular atrophy (X-linked). Some chapters also discuss recent results which suggest that the UPS is heavily regulated by post-translational modifications such as phosphorylation, acetylation, and methylation. The UPS is also heavily regulated by ubiquitination itself. This book contains a research article using PubMed bibliometric data to present current research trends in the UPS. Articles are written so that no one tissue is emphasized to allow readers from any discipline to benefit from this information.
Ubiquitin and Protein Degradation
Ubiquitin and Protein Degradation - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Ubiquitin and Protein Degradation write by Raymond Joseph Deshaies. This book was released on 2005. Ubiquitin and Protein Degradation available in PDF, EPUB and Kindle. Ubiquitin and Protein Degradation, Part B will cover chemical biology, ubiquitin derivatives and ubiquitin-like proteins, deubiquitinating enzymes, proteomics as well as techniques to monitor protein degradation. The chapters are highly methodological and focus on application of techniques. *Second part of the Ubiquitin and Protein Degration series *Topics include: E1 Enzymes, E2 Enzymes, E3 Enzymes, Proteasomes, and Isopeptidases.
Ubiquitin-Proteasome Protocols
Ubiquitin-Proteasome Protocols - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Ubiquitin-Proteasome Protocols write by Cam Patterson. This book was released on 2008-02-04. Ubiquitin-Proteasome Protocols available in PDF, EPUB and Kindle. A collection of cutting-edge techniques for studying ubiquitin-dependent protein degradation via the proteasome. The topics covered range broadly from basic biochemistry to cellular assays to discovery techniques using mass spectrometric analysis. These biochemical and cellular methods are necessary to explore the ubiquitin-proteasome system and ubiquitin-proteasome-dependent functions. State-of-the-art and user-friendly, Ubiquitin-Proteasome Protocols offers novice and experienced bench scientists alike a thorough compendium of readily reproducible techniques that will accelerate discovery, enhance productivity, and permit manipulation of the system for varied research purposes.
