Ubiquitin Code: From Cell Biology to Translational Medicine - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Ubiquitin Code: From Cell Biology to Translational Medicine write by Lingqiang Zhang. This book was released on 2021-12-30. Ubiquitin Code: From Cell Biology to Translational Medicine available in PDF, EPUB and Kindle.
The Ubiquitin Code
The Ubiquitin Code - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Ubiquitin Code write by Manuel S Rodriguez. This book was released on 2022-11-29. The Ubiquitin Code available in PDF, EPUB and Kindle. This volume details novel and popular approaches to decipher the Ubiquitin Code. Chapters guide readers through ubiquitin chain complexity, methods to generate non-hydrolysable ubiquitin-NEDD8, a fully synthetic method for the linear synthesis of fluorescently labelled rhodamine LC3A and LC3B, a HECT ligase-mediated ubiquitylation in vitro, a RNAi-based screening to identify DUBs, a Yuh1 activity assay, a pull-down to isolate K48 and K63 chains using specific nanobodies, identification of NeDDylated protein based in a NEDD8R74K mutant, in vivo identification of NEDDylated proteins from liver diseases, UbL-ID method to identify ubiquitin-like modified proteins, a LC3/GABARAP capturing system, and methods to isolate peptides that are closely associated with proteasomes or trapped inside the core particle of proteasomes in eukaryotic cells, among others. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, The Ubiquitin Code aims to to be a useful practical guide to researches to help further their study in this field.
Ubiquitination and Transmembrane Signaling
Ubiquitination and Transmembrane Signaling - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Ubiquitination and Transmembrane Signaling write by . This book was released on 2016-06-29. Ubiquitination and Transmembrane Signaling available in PDF, EPUB and Kindle. Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. Contains contributions from leading authorities Informs and updates on all the latest developments in the field
Ubiquitin
Ubiquitin - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Ubiquitin write by . This book was released on 2020-12-09. Ubiquitin available in PDF, EPUB and Kindle. The ubiquitin-proteasome pathway consists of ubiquitin, substrate proteins, E1 enzymes, E2 enzymes, E3 enzymes, and proteasome, which acts in a series of enzymatic reaction chains to ubiquitinate substrate proteins such as surplus and misfolded proteins for degradation by the proteasome to maintain the balance between protein synthesis and degradation in a cell and tissue. Moreover, deubiquitinating enzymes can remove the attached ubiquitin chain, which results in a reverse ubiquitination-deubiquitination process involved in multiple biological processes in a cell and tissue. The changes of components in the ubiquitin-proteasome pathway are associated with multiple pathophysiological processes, such as cancers and neurodegenerative diseases. This book presents the new advances in concepts, analytical methodology, and application of ubiquitin-proteasome pathway for clarification of molecular mechanisms and discovery of new therapeutic targets and drugs in different diseases.
Ubiquitin and the Biology of the Cell
Ubiquitin and the Biology of the Cell - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Ubiquitin and the Biology of the Cell write by Jan-Michael Peters. This book was released on 2013-06-29. Ubiquitin and the Biology of the Cell available in PDF, EPUB and Kindle. The last several years have been a landmark period in the ubiquitin field. The breadth of ubiquitin's roles in cell biology was first sketched, and the importance of ubiquitin-dependent proteolysis as a regulatory mechanism gained general acceptance. The many strands of work that led to this new perception are re counted in this book. A consequence of this progress is that the field has grown dramatically since the first book on ubiquitin was published almost a decade ago [M. Rechsteiner (ed. ), Ubiquitin, Plenum Press, 1988]. In this span, students of the cell cycle, transcription, signal transduction, protein sorting, neuropathology, cancer, virology, and immunology have attempted to chart the role of ubi quit in in their particular experimental systems, and this integration of the field into cell biology as a whole continues at a remarkable pace. We hope that for active researchers in the field as well as for newcomers and those on the fence, this book will prove helpful for its breadth, historical perspective, and practical tips. Structural data are now available on many of the components of the ubiquitin pathway. The structures have provided basic insights into the unusual biochemical mechanisms of ubiquitination and proteasome-mediated proteolysis. Because high-speed computer graphics can convey structures more effectively than print media, we have supplemented the figures of the book with a Worldwide Web site that can display the structures in a flexible, viewer-controlled format.
