Understanding Drug Release and Absorption Mechanisms - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Understanding Drug Release and Absorption Mechanisms write by Mario Grassi. This book was released on 2006-12-26. Understanding Drug Release and Absorption Mechanisms available in PDF, EPUB and Kindle. Demand for better reliability from drug delivery systems has caused designers and researchers to move away from trial-and-error approaches and toward model-based methods of product development. Developing such models requires cross-disciplinary physical, mathematical, and physiological knowledge. Combining these areas under a single cover, Under
Understanding Drug Release and Absorption Mechanisms
Understanding Drug Release and Absorption Mechanisms - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Understanding Drug Release and Absorption Mechanisms write by . This book was released on 2007. Understanding Drug Release and Absorption Mechanisms available in PDF, EPUB and Kindle. Demand for better reliability from drug delivery systems has caused designers and researchers to move away from trial-and-error approaches and toward model-based methods of product development. Developing such models requires cross-disciplinary physical, mathematical, and physiological knowledge. Combining these areas under a single cover, Understanding Drug Release and Absorption Mechanisms builds a firm understanding ofall elements needed to conceive, build, and implement successful models of drug release. Written by experts with broad industrial and academic experience, this book discusses the underlying physical principles, shows how to build mathematical models based on these principles, and finally compares the resulting models with experimental results. The authors begin by introducing the basics of modeling, physiological details of gastrointestinal and dermal absorption pathways, rheology, mass transport and thermodynamics, dissolution and partitioning, as well as size effects on the dissolution of crystallites. From this baseline, the authors explore applications in drug release from various delivery systems, specifically matrix systems, microemulsions, and permeability through membranes. Working systematically from theory to working models, Understanding Drug Release and Absorption Mechanisms: A Physical and Mathematical Approach demonstrates the steps involved in designing, building, and implementing realistic and reliable models of drug release without unrealistically simplifying the theoretical parameters.
Controlled Release in Oral Drug Delivery
Controlled Release in Oral Drug Delivery - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Controlled Release in Oral Drug Delivery write by Clive G. Wilson. This book was released on 2011-09-22. Controlled Release in Oral Drug Delivery available in PDF, EPUB and Kindle. Controlled Release in Oral Drug Delivery provides focus on specific topics, complementing other books in the initial CRS series. Each chapter sets the context for the inventions described and describe the latitude that the inventions allow. In order to provide some similar look to each chapter, the coverage includes the historical overview, candidate drugs, factors influencing design and development, formulation and manufacturing and delivery system design. This volume was written along three main sections: the relevant anatomy and physiology, a discussion on candidates for oral drug delivery and the major three groups of controlled release systems: diffusion control (swelling and inert matrices); environmental control (pH sensitive coatings, time control, enzymatic control, pressure control) and finally lipidic systems.
Oral Drug Absorption
Oral Drug Absorption - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Oral Drug Absorption write by Jennifer B. Dressman. This book was released on 2016-04-19. Oral Drug Absorption available in PDF, EPUB and Kindle. Oral Drug Absorption, Second Edition thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. The contributors discuss methods for accurately establishing and validating in vitro/in vivo correlations for both MR and IR formulations, as well as alternative approaches for MR an
Drug Delivery Approaches
Drug Delivery Approaches - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Drug Delivery Approaches write by Bret Berner. This book was released on 2021-08-31. Drug Delivery Approaches available in PDF, EPUB and Kindle. Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes. The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine. Readers will also benefit from the inclusion of: A thorough introduction to the utility of mathematical models in drug development and delivery An exploration of the techniques and applications of physiologically based models to drug delivery Discussions of oral delivery and pharmacokinetic models and oral site-directed delivery A review of integrated transdermal delivery and pharmacokinetics in development An examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanisms Alternative endpoints to pharmacokinetics for topical delivery Perfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.
