Vascular Disruptive Agents for the Treatment of Cancer - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Vascular Disruptive Agents for the Treatment of Cancer write by Tim Meyer. This book was released on 2010-09-02. Vascular Disruptive Agents for the Treatment of Cancer available in PDF, EPUB and Kindle. Angiogenesis (formation of new vessels from pre-existing ones) is a crucial early event in the process of tumor development. New vessels supply the tumor with nutrients that are needed for further local growth and enable distant metastases (Folkman 1995). Judah Folkman (1971) highlighted the potential therapeutic imp- cations of tumor angiogenesis. He hypothesized that if tumor angiogenesis is inhibited, then tumor growth and metastasis will be impaired greatly or even impossible. The subsequent quest for endogenous and exogenous inhibitors of angiogenesis has yielded a variety of promising therapeutic agents that block one or more angiogenic pathways, a few of which have been approved by the FDA (e. g. , bevacizumab, sorafenib, sunitinib) for use as single agents or in combination with chemotherapy in specific populations of cancer patients (Sessa et al. 2008). There has also been a dramatic expansion in the exploration of novel anti-angiogenic agents pre-clinically and in clinical trials (Ferrara 2002). Some of the most promising data comes from the development of agents that inhibit one of the key growth factors involved in tumor angiogenesis – vascular endothelial growth factor (VEGF) (Ferrara et al. 2003). Bevacizumab is a monoclonal antibody against VEGF that was the first an- angiogenic agent that improved significantly the overall survival of patients with colorectal and non-squamous non-small cell lung cancer (Ferrara et al. 2005). Various agents that target tumor angiogenesis are currently under investigation in different cancer types in many clinical trials (Ferrara and Kerbel 2005).
Vascular Disruptive Agents for the Treatment of Cancer
Vascular Disruptive Agents for the Treatment of Cancer - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Vascular Disruptive Agents for the Treatment of Cancer write by . This book was released on 2011-07-11. Vascular Disruptive Agents for the Treatment of Cancer available in PDF, EPUB and Kindle.
Vascular-Targeted Therapies in Oncology
Vascular-Targeted Therapies in Oncology - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Vascular-Targeted Therapies in Oncology write by Dietmar W. Siemann. This book was released on 2006. Vascular-Targeted Therapies in Oncology available in PDF, EPUB and Kindle. Vascular-Targeted Therapies in Oncology provides an interesting insight to the current status and future potential of vascular-disrupting approaches in cancer management. Emphasis is placed on target development, preclinical assessment, and the use of such targeted approaches in combination with conventional treatment regimens and the current clinical status of these therapies.
Preclinical Evaluation of Cardiotoxicity Associated with Vascular Disrupting Agents Used for the Treatment of Cancer
Preclinical Evaluation of Cardiotoxicity Associated with Vascular Disrupting Agents Used for the Treatment of Cancer - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Preclinical Evaluation of Cardiotoxicity Associated with Vascular Disrupting Agents Used for the Treatment of Cancer write by Asma K. I. Mohamed. This book was released on 2021. Preclinical Evaluation of Cardiotoxicity Associated with Vascular Disrupting Agents Used for the Treatment of Cancer available in PDF, EPUB and Kindle.
Antiangiogenic Agents in Cancer Therapy
Antiangiogenic Agents in Cancer Therapy - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Antiangiogenic Agents in Cancer Therapy write by Beverly A. Teicher. This book was released on 1998-12-28. Antiangiogenic Agents in Cancer Therapy available in PDF, EPUB and Kindle. Beverly Teicher and a panel of distinguished investigators survey the state-of-the-art of antiangiogenesis research from the lab bench to clinical trials. Timely and authoritative, the contributors summarize our current understanding of tumor growth and its dependence on vascular development, as well as the present status of antiangiogenic agents in preclinical and clinical development. In addition, the book also examines what is known about the mechanisms by which these therapeutic agents interfere with tumor vasculature and grapples with the problem of establishing criteria by which to assess their clinical efficacy. Antiangiogenic Agents in Cancer Therapy offers a unique cutting-edge compendium of antiangiogenic research, taking stock of what has been accomplished , where the experimental therapeutics of antiangiogenic agents is going, and the continuing evolution of their role in cancer treatment and novel drug development.
