WHO consolidated guidelines on tuberculosis. Module 3 - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook WHO consolidated guidelines on tuberculosis. Module 3 write by World Health Organization. This book was released on 2020-06-22. WHO consolidated guidelines on tuberculosis. Module 3 available in PDF, EPUB and Kindle. The political declaration of the first United Nations (UN) high-level meeting on tuberculosis (TB) calls countries to diagnose and treat 40 million people with TB globally between 2018 and 2022. Traditionally, in most countries, TB diagnosis has been performed using sputum-smear microscopy, a method developed more than 100 years ago, with suboptimal sensitivity. In recent years new technologies have emerged based on the detection of mycobacterial DNA or mycobacterial antigens. Over the past decade the World Health Organization (WHO) has published a number of guidelines developed by WHO-convened Guideline Development Groups (GDGs), using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to summarize the evidence and to formulate policy recommendations and accompanying remarks. The present document "WHO consolidated guidelines on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection" consolidates five guidelines developed by WHO between 2016 and 2020. Earlier guidelines on diagnostics that were not developed according to the GRADE approach have not been included in this document. The WHO Consolidated Guidelines on Tuberculosis will group all TB recommendations in one document and will be complemented by matching modules of an operational handbook. The handbook will provide practical advice on how to put in place the recommendations at the scale needed to achieve national and global impact. A range of new diagnostic technologies have been endorsed by WHO during the past decade. These are listed below: - real-time polymerase chain reaction (PCR) assays - for example, Xpert MTB/RIF(r) (Ultra) (cartridge-based) and TruenatTM (chip-based);- line probe assays (LPAs) - for example, GenoType(r) MTBDRplus v1 and v2, GenoscholarTM NTM+MDRTB II and GenoType(r) MTBDRsl;- loop-mediated isothermal amplification (LAMP) - for example, TB-LAMP; and- antigen detection in a lateral flow format (biomarker-based detection) - for example, Alere DetermineTM TB LAM Ag. The present "WHO consolidated guidelines on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection" provides background, justification and recommendations on these technologies. The document includes new recommendations on molecular assays intended as initial tests for the diagnosis of pulmonary and extrapulmonary TB and rifampicin resistance in adults and children.
WHO consolidated guidelines on tuberculosis. Module 3
WHO consolidated guidelines on tuberculosis. Module 3 - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook WHO consolidated guidelines on tuberculosis. Module 3 write by World Health Organization. This book was released on 2024-03-08. WHO consolidated guidelines on tuberculosis. Module 3 available in PDF, EPUB and Kindle. The “WHO consolidated guidelines on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection, third edition” is the latest document replacing the one issued in 2021. This latest edition includes new recommendations on the use of a new class of diagnostic technologies: targeted next-generation sequencing (NGS) tests for the diagnosis of drug-resistant tuberculosis (TB). The recommendations provide a novel approach for the rapid detection of drug resistance to new anti-TB drugs using the latest technologies. The consolidated guideline provides background, justification and recommendations on these and earlier endorsed TB diagnostic technologies. This document is accompanied by the “WHO operational handbook on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection, third edition”, which aims at facilitating the implementation of the WHO recommendations by the Member States, technical partners, and others involved in managing patients with TB and DR-TB.
WHO consolidated guidelines on tuberculosis. Module 3
WHO consolidated guidelines on tuberculosis. Module 3 - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook WHO consolidated guidelines on tuberculosis. Module 3 write by World Health Organization. This book was released on 2021-07-05. WHO consolidated guidelines on tuberculosis. Module 3 available in PDF, EPUB and Kindle. The "WHO consolidated guidelines on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection 2021 update" is the latest document replacing the one issued in 2020. Three new nucleic acid amplification test (NAAT) classes are endorsed by WHO and included in the latest consolidated guideline: 1. moderate complexity automated NAATs, recommended for the initial detection of TB and resistance to rifampicin and isoniazid, providing more options for early diagnosis of TB and rifampicin-resistant TB but also addressing an important gap in the rapid diagnosis of isoniazid-resistant and rifampicin-susceptible TB;2. low complexity automated NAATs, recommended for the detection of resistance to isoniazid and second-line anti-TB agents, which will improve access to testing of resistance to fluoroquinolones at peripheral level; and3. high complexity reverse hybridization-based NAATs, recommended for the detection of pyrazinamide resistance, representing the first molecular tests for resistance determination to this drug. The consolidated guideline provides background, justification and recommendations on these and earlier endorsed TB diagnostic technologies. This document is accompanied by the "WHO operational handbook on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection 2021 update", which aims at facilitating the implementation of the WHO recommendations by the Member States, technical partners, and others involved in managing patients with TB and DR-TB.
WHO consolidated guidelines on tuberculosis. Module 3
WHO consolidated guidelines on tuberculosis. Module 3 - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook WHO consolidated guidelines on tuberculosis. Module 3 write by World Health Organization. This book was released on 2022-08-12. WHO consolidated guidelines on tuberculosis. Module 3 available in PDF, EPUB and Kindle. The consolidated and updated guidelines in the current Module 3: Diagnosis. Tests for TB infection brings together, without modifications, all valid and evidence-based recommendations from the 2011 and 2020 guideline updates and adds a new section based on the recent round of guidelines development in 2022 – the recommendations on M. tuberculosis antigen-based skin tests for the diagnosis of TB infection.
WHO consolidated guidelines on tuberculosis. Module 2
WHO consolidated guidelines on tuberculosis. Module 2 - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook WHO consolidated guidelines on tuberculosis. Module 2 write by World Health Organization. This book was released on 2021-03-22. WHO consolidated guidelines on tuberculosis. Module 2 available in PDF, EPUB and Kindle. The WHO consolidated guidelines on tuberculosis. Module 2: screening – systematic screening for tuberculosis disease is an updated and consolidated summary of WHO recommendations on systematic screening for tuberculosis (TB) disease, containing 17 recommendations for populations in which TB screening should be conducted and tools to be used for TB screening. TB screening is strongly recommendations for household and close contacts of individuals with TB, people living with HIV, miners exposed to silica dust, and prisoners. In addition, screening is conditionally recommended for people with risk factors for TB attending health care, and for communities with risk factors for TB and limited access to care (e.g. homeless, urban poor, refugees, migrants). General population screening is recommended in high-burden settings (0.5% prevalence or higher). Symptoms, chest radiography (CXR), and molecular WHO-recommended rapid diagnostic tests for TB are recommended as screening tools for all adults eligible for screening. Computer-aided detection programmes are recommended as alternatives to human interpretation of CXR in settings where trained personnel are scarce. For people living with HIV, C-reactive protein is also a good screening tool. This guideline document is accompanied by an operational handbook, the WHO operational handbook on tuberculosis. Module 2: screening – systematic screening for tuberculosis disease, that presents principles of screening, steps in planning and implementing a screening programme, and algorithm options for screening different populations.
